Get Help with Cravings, Regulate Blood Sugar, and Increase Insulin Sensitivity Through Natural Appetite Control Supplementation

Master Coach Ken Yu | January 14, 2025

Amid the growing popularity of glucagon-like peptide-1 (GLP-1) therapies such as Ozempic® or Wegovy®, many individuals seek to regulate insulin, lower blood glucose levels, and enhance satiety. However, natural appetite control supplements offer a cost-effective alternative with evidence-based benefits.

Bodybuilding.com’s Signature Appetite Control supplement combines 400 mcg Chromax® (a patented form of chromium picolinate), 200 mg Ceylon Cinnamon Powder, 200 mg Garcinia Cambogia Extract, 200 mg Glucovantage® (a proprietary dihydroberberine formulation), 200 mg Gymnema Extract, and 200 mg White Kidney Bean Extract. This blend is designed to support craving management and fat metabolism.

Ingredient Breakdown: Exploring the Key Benefits

Each ingredient in Signature Appetite Control is selected for its scientific backing and synergistic effects:

Chromax® (Chromium Picolinate)

Chromax® is a branded chromium picolinate—a highly bioavailable form of chromium, an essential trace mineral for metabolism and blood sugar regulation. Supplementation with chromium supports glucose homeostasis, improves insulin sensitivity, reduces cravings, enhances appetite control, and facilitates healthy weight management. Clinical studies have demonstrated benefits for individuals with metabolic syndrome and type 2 diabetes, highlighting its role in metabolic health.[1]

Garcinia Cambogia Extract

Garcinia Cambogia Extract is derived from the fruit rind of the Garcinia cambogia tree. Its active component, hydroxycitric acid (HCA), supports appetite control and weight management by increasing serotonin (a neurotransmitter linked to satiety) and inhibiting carbohydrate-to-fat conversion. Preliminary trials suggest short-term efficacy in weight loss.[2–4]

Ceylon Cinnamon Powder

Ceylon cinnamon (Cinnamomum zeylanicum) has been used in Southeast Asian traditional medicine for its antimicrobial, antiparasitic, antioxidant, and glucose-lowering properties. It regulates blood sugar by improving insulin sensitivity, reduces hunger via enhanced satiety, and exerts mild thermogenic effects that may boost metabolism. While clinical evidence is mixed, most studies confirm consistent improvements in fasting glucose levels. For example, a small trial found that 28 participants experienced reduced cholesterol and blood pressure after three months of supplementation.[5–6]

Glucovantage® (Dihydroberberine)

Glucovantage® is a patented formulation of dihydroberberine—an active metabolite of berberine, a compound renowned for supporting healthy blood sugar levels and insulin sensitivity. A meta-analysis of clinical trials demonstrated berberine’s efficacy in addressing obesity and diabetes by reducing triglycerides, total cholesterol, low-density lipoprotein (LDL), and fasting glucose. However, berberine’s low bioavailability limits its effectiveness; Glucovantage® overcomes this with enhanced absorption and longer-lasting effects.[7]

Gymnema Extract

Gymnema Extract, sourced from the leaves of Gymnema sylvestre, is a cornerstone of Ayurvedic medicine. It reduces the perception of sweetness, making sugary foods less appealing and aiding in craving management. Emerging research suggests benefits for body weight, body mass index (BMI), LDL cholesterol, glycemic control, and lipid levels—though additional studies are needed to confirm these findings.[8–9]

White Kidney Bean Extract

White Kidney Bean Extract, derived from Phaseolus vulgaris seeds, inhibits alpha-amylase—an enzyme responsible for breaking down carbohydrates. By blocking carbohydrate absorption, it supports appetite control and weight management by limiting calorie intake from carbs. Preliminary evidence indicates this mechanism promotes satiety, reduces cravings, and decreases between-meal snacking—though research is ongoing.[10–11]

Takeaways

For individuals seeking a natural supplement to manage cravings, regulate blood sugar, and improve insulin sensitivity, Signature Appetite Control is a compelling option. Its evidence-backed formulation combines ingredients that:

• Boost metabolism

• Lower fasting glucose levels

• Reduce the appeal of sugary foods

• Block carbohydrate absorption

• Enhance satiety via serotonin modulation

References

1. Maret W. Chromium Supplementation in Human Health, Metabolic Syndrome, and Diabetes. Met Ions Life Sci. 2019 Jan 14;19:/books/9783110527872/9783110527872-015/9783110527872-015.xml. doi: 10.1515/9783110527872-015. PMID: 30855110.

2. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. Garcinia Cambogia. 2019 Feb 13. PMID: 31643417.

3. Semwal RB, Semwal DK, Vermaak I, Viljoen A. A comprehensive scientific overview of Garcinia cambogia. Fitoterapia. 2015 Apr;102:134–48. doi: 10.1016/j.fitote.2015.02.012. Epub 2015 Feb 27. PMID: 25732350.

4. Fassina P, Scherer Adami F, Terezinha Zani V, Kasper Machado IC, Garavaglia J, Quevedo Grave MT, Ramos R, Morelo Dal Bosco S. THE EFFECT OF GARCINIA CAMBOGIA AS COADJUVANT IN THE WEIGHT LOSS PROCESS. Nutr Hosp. 2015 Dec 1;32(6):2400–8. doi: 10.3305/nh.2015.32.6.9587. PMID: 26667686.

5. Ranasinghe P, Jayawardena R, Pigera S, Wathurapatha WS, Weeratunga HD, Premakumara GAS, Katulanda P, Constantine GR, Galappaththy P. Evaluation of pharmacodynamic properties and safety of Cinnamomum zeylanicum (Ceylon cinnamon) in healthy adults: a phase I clinical trial. BMC Complement Altern Med. 2017 Dec 28;17(1):550. doi: 10.1186/s12906-017-2067-7. PMID: 29282046; PMCID: PMC5745724.

6. Rafehi H, Ververis K, Karagiannis TC. Controversies surrounding the clinical potential of cinnamon for the management of diabetes. Diabetes Obes Metab. 2012 Jun;14(6):493–9. doi: 10.1111/j.1463-1326.2011.01538.x. Epub 2011 Dec 27. PMID: 22093965.

7. Ye Y, Liu X, Wu N, Han Y, Wang J, Yu Y, Chen Q. Efficacy and Safety of Berberine Alone for Several Metabolic Disorders: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Front Pharmacol. 2021 Apr 26;12:653887. doi: 10.3389/fphar.2021.653887. PMID: 33981233; PMCID: PMC8107691.

8. Zuñiga LY, González-Ortiz M, Martínez-Abundis E. Effect of Gymnema sylvestre Administration on Metabolic Syndrome, Insulin Sensitivity, and Insulin Secretion. J Med Food. 2017 Aug;20(8):750–4. doi: 10.1089/jmf.2017.0001. Epub 2017 May 1. PMID: 28459647.

9. Devangan S, Varghese B, Johny E, Gurram S, Adela R. The effect of Gymnema sylvestre supplementation on glycemic control in type 2 diabetes patients: A systematic review and meta-analysis. Phytother Res. 2021 Dec;35(12):6802–12. doi: 10.1002/ptr.7265. Epub 2021 Sep 1. PMID: 34467577.

10. Nolan R, Shannon OM, Robinson N, Joel A, Houghton D, Malcomson FC. It's No Has Bean: A Review of the Effects of White Kidney Bean Extract on Body Composition and Metabolic Health. Nutrients. 2020 May 13;12(5):1398. doi: 10.3390/nu12051398. PMID: 32414090; PMCID: PMC7284421.

11. Jäger R, Abou Sawan S, Purpura M, Grube B, Röske Y, De Costa P, Chong PW. Proprietary alpha-amylase inhibitor formulation from white kidney bean (Phaseolus vulgaris L.) promotes weight and fat loss: a 12-week, double-blind, placebo-controlled, randomized trial. Sci Rep. 2024 Jun 3;14(1):12685. doi: 10.1038/s41598-024-63443-8. PMID: 38830962; PMCID: PMC11148185.