Bodybuilding.com Elevates Signature™ Series with 2025 Formula Refresh

By BBCOM Editors | January 10, 2025

First launched in 2018, Bodybuilding.com’s in-house Signature™ line was built on a core mission: to make quality fitness and health solutions accessible to all—no exclusivity, no barriers. The initial series delivered foundational supplements—including whey protein, multivitamins, creatine, and BCAAs—to gym-goers and fitness enthusiasts, prioritizing simplicity over unnecessary complexity.

Seven years later, we’ve reimagined the line to not only meet modern customer expectations but to set a new standard for excellence in sports nutrition. The enhanced Signature™ Series eliminates all artificial dyes and colorants, implements elevated ingredient sourcing protocols, and expands the lineup with over six new products—all designed to deliver what we believe is one of the market’s top supplement offerings.

Dive into the details below to explore the 2025 Signature™ Series, featuring both returning favorites and new additions:

1. Signature™ 100% Whey Protein

Bodybuilding.com Signature™ 100% Whey blends all three whey fractions—concentrate, isolate, and hydrolyzate—to deliver the unique benefits of each. Each 32-gram scoop provides 25 grams of protein, 2 grams of carbohydrates, and 1 gram of fat, alongside 11.9 grams of essential amino acids (EAAs) and 5.5 grams of branched-chain amino acids (BCAAs). Digestive enzymes are included to support optimal protein breakdown and absorption.

2. Signature™ 100% Whey Isolate

Bodybuilding.com Signature™ 100% Whey Isolate delivers 25 grams of protein per 30-gram scoop, with only 2 grams of carbohydrates and 0.5 grams of fat. It also contains 11.9 grams of EAAs and 5.5 grams of BCAAs. Sourced exclusively from U.S. farms, this high-purity whey isolate maintains the line’s commitment to quality.

3. Signature™ Creatine

Creatine is the supplement that established Bodybuilding.com as a trusted name in sports nutrition. Signature™ Creatine Monohydrate combines premium quality with a competitive price point. For convenience, the micronized powder features a 200-mesh rating, ensuring easy dissolution in any beverage—simplifying daily creatine intake.

4. Signature™ EAAs

Bodybuilding.com Signature™ EAAs feature a research-backed formulation designed to support muscle growth, accelerate recovery, and maintain hydration. Each 10-gram serving provides 5.2 grams of BCAAs in a 2:1:1 leucine:isoleucine:valine ratio, plus the full spectrum of remaining EAAs (histidine, methionine, phenylalanine, threonine, tryptophan) and electrolytes (sodium, potassium, magnesium, calcium).

5. Signature™ BCAAs (COMING SOON)

While EAAs provide comprehensive muscle-building support, Signature™ BCAAs offer a highly effective, cost-efficient option for individuals targeting training-specific goals. Rapidly absorbed, BCAAs are ideal for intra-workout use—particularly for muscle preservation and immediate energy delivery during exercise.

6. Signature™ Diuretic

Bodybuilding.com Signature™ Diuretic is a safe, effective solution for individuals seeking to reduce bloating, boost metabolism, or enhance fat oxidation during workouts. Formulated with primarily natural ingredients, it integrates seamlessly into any supplement regimen.

7. Signature™ Triple Carnitine

Bodybuilding.com™ Signature Triple Carnitine combines three carnitine forms to target distinct physiological benefits: (1) L-Carnitine Tartrate for enhanced fat metabolism; (2) Acetyl L-Carnitine HCl for cognitive focus; and (3) L-Carnitine Fumarate for increased energy production.

8. Signature™ Appetite Control

Signature™ Appetite Control is designed for individuals seeking to manage cravings, regulate blood sugar, and improve insulin sensitivity. Formulated with natural ingredients, it supports metabolism, reduces fasted glucose levels, diminishes cravings for sugary foods, inhibits carbohydrate absorption, and enhances satiety via serotonin modulation.

9. Signature™ Electrolytes (COMING SOON)

Bodybuilding.com Signature™ Electrolytes feature a balanced blend of sodium, potassium, magnesium, and calcium to support peak muscular performance, contractile function, and hydration. Each serving provides 5.4 grams of electrolytes—including 900 mg of potassium, 680 mg of sodium, 100 mg of calcium, and 50 mg of magnesium—optimized for pre-, intra-, and post-workout hydration. The ratio is tailored to maximize results for active lifestyles.

10. Signature™ SHRED

Signature™ Shred combines CLA, Garcinia, and CaloriBurn® GP in a powerful formula designed to deliver sustained energy, enhanced fat metabolism, and optimal calorie expenditure. Backed by scientific research, this powder supports fat loss, muscle retention, and the achievement of a balanced, lean body composition.

11. Signature™ Plant Protein

Scientific research consistently shows animal-based proteins outperform plant-based alternatives due to their complete amino acid profiles and higher leucine content. Traditional plant-based powders (e.g., soy, pea) are suboptimal because legumes lack one of the nine essential amino acids (methionine), resulting in incomplete protein profiles. Signature™ Plant Protein addresses this by combining pea, rice, and fava bean proteins into a complete complex—delivering the missing methionine and elevated leucine levels to support protein synthesis.

Each scoop provides 25 grams of protein, 9.8 grams of EAAs, and 4.7 grams of BCAAs. Medium-chain triglycerides (MCTs) from coconut oil are included for rapid energy and ketone production. This product is ideal for vegan, vegetarian, and flexitarian lifestyles.

12. Signature™ Glutamine (COMING SOON)

Bodybuilding.com Signature™ Glutamine provides a clinically effective 5-gram dose per serving to stimulate protein synthesis and support muscle growth. The 100% micronized powder features a 200-mesh rating for easy dissolution in any liquid, enhancing rapid absorption and bioavailability.

13. Signature™ Test Booster (COMING SOON)

Signature™ Test Booster features a blend of ingredients clinically shown to support natural testosterone production, including 600 mg of KSM-66® Ashwagandha, 300 mg of fenugreek, 300 mg of Tribulus terrestris, plus zinc, magnesium, and vitamin B6. Elevated testosterone levels support muscle growth, increased metabolism, reduced body fat, and enhanced exercise recovery.

14. Signature™ Caffeine

Signature™ Caffeine Capsules are uniquely formulated with 100% Coffea robusta extract—engineered for sports-focused individuals seeking a powerful energy boost. Each capsule delivers 200 mg of natural caffeine (a medium dose) to enhance energy, focus, and performance. Coffea robusta offers a higher caffeine concentration than Arabica beans and is cultivated using sustainable, eco-friendly practices that align with environmental and personal wellness goals. It’s ideal for athletes looking to amplify training with a naturally sourced, sustainable energy solution.

15. Signature™ Multivitamin (COMING SOON)

Signature™ Multivitamin is tailored for athletes, fitness enthusiasts, and anyone prioritizing optimal health and well-being. This comprehensive multivitamin-mineral formula addresses the body’s full spectrum of essential nutrient needs. Formulated to support lean muscle growth, accelerate recovery, and enhance overall health, it’s optimized for active, high-performance lifestyles.

Key ingredients include vitamins A, C, D3, E, K1, thiamin, riboflavin, niacin, folate, B5, B6, and B12; plus minerals calcium, magnesium, zinc, selenium, copper, and chromium. Additional components include 500 mg of ashwagandha, 50 mg of cinnamon powder, 50 mg of the probiotic Bacillus coagulans, and 50 mg of DigeSEB™—a patented blend of five digestive enzymes (amylase, lactase, protease, lipase, cellulase). It also features fruit and vegetable blends, lutein, lycopene, boron, and vanadium.

16. Signature™ Greens (COMING SOON)

Signature™ Greens is a comprehensive superfood powder featuring 5 grams of key ingredients—including alfalfa grass, wheatgrass, barley grass, kale, oat grass, chlorella, astragalus, and turmeric—plus fruit (strawberry, raspberry, blueberry, tart cherry, elderberry, cranberry) and vegetable (broccoli, broccoli sprouts, tomato, carrot, spinach, kale) blends. It also contains 250 mg of DigeSEB™, a patented digestive enzyme blend (amylase, lactase, protease, lipase, cellulase), and 125 mg of mushroom extracts (cordyceps, reishi, king trumpet, shiitake, lion’s mane, turkey tail).

17. Signature™ Pre-Workout

Signature™ Pre-Workout features research-backed ingredients to support muscle growth, energy production, muscular endurance, blood flow, mental focus, and hydration. A key differentiator from other pre-workouts is the inclusion of L-leucine—a branched-chain amino acid shown to enhance muscle mass, support fat loss, and reduce muscular fatigue.

The enhanced Signature™ Series is now available—engineered to support any fitness goal you pursue. It’s time to elevate your training.